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Alendronate isn't suitable for everyone. It belongs to a group of drugs called bisphosphonates, which are the most commonly used treatment for people with osteoporosis. Restriction: Authority required (STREAMLINED) All information is observation-only. Patients should only swallow Alendronic Acid whole. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). This is not to say that osteoporosis is not also a cause for concern; unfortunately, it is. This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially 'sodium-free.'. If suitable, they may suggest a 'treatment break', where you stop taking alendronate for a while before starting it again. Alendronate is an osteoporosis medication. Patients (or their carers) should be advised to stop taking alendronic acid and to seek medical attention if they develop symptoms of oesophageal irritation such as dysphagia, new or worsening heartburn, pain on swallowing or retrosternal pain. Voluntary cooperation of the patient in following a prescribed regimen. This drug is also used to treat Paget's disease. A subset had recurrence of symptoms when rechallenged with the same medicinal product or another bisphosphonate. Taking alendronic acid can help if you have, or are at risk of developing, osteoporosis. Patients should be instructed that if they miss a dose of Alendronic Acid Once Weekly, they should take one tablet on the morning after they remember. Patient does not provide medical advice, diagnosis or treatment. In osteoporosis studies, alendronate was effective when administered at least 30 minutes before the first food or beverage of the day. Alendronate is also indicated to increase bone mass in men with osteoporosis and to treat people with osteoporosis induced by glucocorticoid steroids such as prednisone. [2] It is taken by mouth. My doctor prescribed Adcal D3 2 tabs twice per day and Alendronic Acid 1 tablet weekly. Main outcome measures: Co-primary efficacy endpoints were 12-month change (%) from baseline in mean lumbar spine and total hip BMD. Different individuals may respond to medication in different ways. Number of reports submitted per year: Drugs being compared in this study: Alendronic Acid ( alendronate sodium) eHealthMe is studying from 12,554 Alendronic acid users for its effectiveness, alternative drugs and more. It's generally tolerated a bit better than Fosamax. That doesn't seem to be a valid email address. Alendronic acid is contraindicated in: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. The underlying cause for concern is these drugs' staggeringly long half-life (which refers to how long they remain in one's system): up to ten years! If you notice any other problems or changes, check the patient information leaflet that comes with your alendronate. How do I take it? Our specialist nurses are also here for you. However, it usually takes 6-12 months of ongoing medication to get its full benefit. Bisphosphonates are often the first treatment you'll be offered if you have weaker bones. For patients who develop osteonecrosis of the jaw while on bisphosphonate therapy, dental surgery may exacerbate the condition. The use of the eHealthMe site and its content is at your own risk. Currently clinicians offer bisphosphonates to people with osteoporosis who are eligible for risk assessment and who have a high fracture risk. FIT consisted of two placebo-controlled studies using alendronate daily (5 mg daily for two years and 10 mg daily for either one or two additional years): - FIT 1: A three-year study of 2,027 patients who had at least one baseline vertebral (compression) fracture. There may be something that suits you better. Some people have had problems getting alendronic acid 70mg tablets in recent months. Alendronic acid has active ingredients of alendronate sodium. To permit adequate absorption of alendronate: Alendronic Acid must be taken at least 30 minutes before the first food, beverage, or medicinal product of the day with plain water only. Brochure Corsantrum Technology Sumul Dairy Road, Surat TrustSEAL Verified Verified Exporter Risedronate also comes in generic form. Alendronate is also indicated to increase bone mass in men with osteoporosis and to treat people with osteoporosis induced by glucocorticoid steroids such as prednisone. Adverse events were monitored throughout. It is often used in osteoporosis. Hirschmann S, Gibel A, Tsvelikhovsky I, Lisker A. Lee WY, Sun LM, Lin MC, Liang JA, Chang SN, Sung FC, Muo CH, Kao CH. Osteonecrosis of the external auditory canal has been reported with bisphosphonates, mainly in association with long-term therapy. Using a noodle I lift the leg up and push to the bottom of the pool one leg at a time. Egton Medical Information Systems Limited. Description: Alendronic acid is an aminobisphosphonate which inhibits the activity on osteoclasts or osteoclast precursors, thus decreasing the rate of bone resorption leading to an indirect increase in bone mineral density. No evidence of saturation of bone uptake was found after chronic dosing with cumulative intravenous doses up to 35 mg/kg in animals. To bookmark a medicine you must sign up and log in. Don't worry if it takes a few weeks to organise the effect of your treatment will wear off slowly. Both are expected to be very effective, but it is not known which one will work best. HDPE Bottle pack: 30, 50, 60 and 250 tablets. In post-marketing experience, these symptoms have rarely been severe and/or incapacitating (see section 4.8). Alendronate (Fosamax) is currently (April 1999) the only bisphosphonate approved by the United States Food and Drug Administration (FDA) for use in osteoporosis. 2022 eHealthMe.com. Alendronate is not excreted through the acidic or basic transport systems of the kidney in rats, and thus it is not anticipated to interfere with the excretion of other medicinal products by those systems in humans. Phase IV trials are used to detect adverse drug outcomes and monitor effectiveness after drugs are approved to the market. Clinical judgement of the treating physician should guide the management plan of each patient based on individual benefit/risk assessment. Alendronate is an osteoporosis medication. The terminal half-life in humans is estimated to exceed ten years, reflecting release of alendronate from the skeleton. Oesophageal reactions (sometimes severe and requiring hospitalisation), such as oesophagitis, oesophageal ulcers and oesophageal erosions, rarely followed by oesophageal stricture, have been reported in patients receiving alendronate. It's important to take your alendronate regularly, as advised by your doctor or pharmacist. The oral bisphosphonate medicines prescribed in the UK are: alendronate (Fosamax, Fosavance) sodium clodronate (Bonefos, Loron) disodium etidronate (Didronel, Didronel PMO) ibandronate. During bisphosphonate treatment patients should be advised to report any thigh, hip or groin pain and any patient presenting with such symptoms should be evaluated for an incomplete femur fracture. I would be interested in any data that can be provided. Frequency in Clinical Trials was similar in the drug and placebo group. Hypocalcaemia must be corrected before initiating therapy with alendronate (see section 4.3).Other disorders affecting mineral metabolism (such as vitamin D deficiency and hypoparathyroidism) should also be effectively treated before starting this medicinal product. Methods: This was a 12-month extension to the Fosamax Actonel Comparison Trial international study (FACTS). Alendronate helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. For the full list of excipients, see section 6.1. We want the forums to be a useful resource for our users but it is important to remember that the forums are Alendronic acid (Binosto) for the treatment of postmenopausal osteoporosis (April 2016) Recommended with restrictions Medicinal forms There can be variation in the licensing of different medicines containing the same drug. Copyright Royal Osteoporosis Society 2022, Exercise and physical activity for osteoporosis, Alendronate is an osteoporosis medication. The median percentage improvement in lumbar spine BMD with zoledronic acid was 5.5% (Interquartile range (IQR) 0.2 to 9.1%) and with alendronate was 6.45% (IQR 1.8 to 10.4%). Other drugs that have the same active ingredients (e.g. No adverse experiences attributable to their concomitant use were identified. Does anyone either take or knows anything about the effects that people have or have had with this medication? Help us improve emc by letting us know which of the following best describes you, 2. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. No other interactions with medicinal products of clinical significance are anticipated. The impact of variables such as time between cessation of bisphosphonate therapy to conception, the particular bisphosphonate used, and the route of administration (intravenous versus oral) on the risk has not been studied. To view the changes to a medicine you must sign up and log in. To this end, I use a rollator, both indoors and outside. They can include: If you do get side effects, they shouldn't last for long. Alendronate Sodium - vs - Alendronic Acid in osteoarthritis Based on 154 reports of osteoarthritis community members alendronate sodium Drug alendronic acid Drug VS Ranking #210 Most tried #140 NA Most effective #123 Effectiveness Reports 0% extremely well 0% 10% very well 13% 50% fairly well 13% 40% Non significant 75% More from the community Bisphosponates are prescribed to help your bones stay as strong as possible. In addition, a statistically significant reduction was found in the incidence of hip fractures (1.1% vs. 2.2%, a reduction of 51%). These transverse or short oblique fractures can occur anywhere along the femur from just below the lesser trochanter to just above the supracondylar flare. respect of any healthcare matters. Bone, joint, and/or muscle pain has been reported in patients taking bisphosphonates. Connect with others living with osteoporosis. Alendronate sodium has been studied in a small number of patients with osteogenesis imperfecta under the age of 18 years. The mean steady-state volume of distribution, exclusive of bone, is at least 28 litres in humans. Our phase IV clinical studies alone cannot establish cause-effect relationship. Discontinuation of bisphosphonate therapy in patients suspected to have an atypical femur fracture should be considered pending evaluation of the patient, based on an individual benefit risk assessment. Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. autologous glioma tumor cell lysates (inactivated), allogeneic glioma tumor cell lysates (inactivated), allogeneic glioma tumor cells (inactivated), autologous glioma tumor cells (inactivated), date of withdrawal: 02/05/2022, Initial authorisation, Last updated: 17/06/2022. But not every problem has a solution, even though doctors and pharmaceutical companies would like us to think otherwise. Alendronate is also referred to as Alendronic acid. Personalize this study to your gender and age (0-99+). A risk to the newborns/infants cannot be excluded. I believe there are exercises you can do in the pool that are weight bearing by using resistance and stairs! Fractures are often bilateral; therefore the contralateral femur should be examined in bisphosphonate-treated patients who have sustained a femoral shaft fracture. If you can't get your usual tablets, speak to your local pharmacist. Take one Alendronic Acid . In this study, a significant difference was observed in the analysis of the subgroup of osteoporotic women (37% of the global population who correspond with the above definition of osteoporosis) in the incidence of hip fractures (alendronate 1.0% vs. placebo 2.2%, a reduction of 56%) and in the incidence of 1 vertebral fracture (2.9% vs. 5.8%, a reduction of 50%). Its important to read the information in the patient information leaflet that comes with your treatment. Alendronate can cause local irritation of the upper gastro-intestinal mucosa. There is no evidence that alendronate is metabolised in animals or humans. Preclinical studies have shown preferential localisation of alendronate to sites of active resorption. Ares, Odyssey Business Park, West End Road, Odyssey Business Park, Ares Block, West End Road, South Ruislip, Middlesex, HA4 6QD. With this condition, your bones become thin and weak, and break easily. For 3 years now I've been taking one capsule of alendronic acid a week. I favour the pool. For patients requiring dental procedures, there are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw. However, there is a theoretical risk of foetal harm, predominantly skeletal, if a woman becomes pregnant after completing a course of bisphosphonate therapy. Since NSAID use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate. Alendronate is given as a weekly pill. With this. Dependiong on your vulnerabilities, you may need to consult with a physiotherapist for techniques to protect your spine. The situation has now improved, but the following information may be helpful if there is still a shortage in your area. Alendronic acid | C4H13NO7P2 | CID 2088 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . In patients with these conditions, serum calcium and symptoms of hypocalcaemia should be monitored during therapy with Alendronic Acid. https://www.iofbonehealth.org/bisphosphonates. Use of the forums is subject to our Terms of Use Calcium can affect how the medication is absorbed. When suggestions are available use up and down arrows to review and ENTER to select. bone death). we compared the efficacy and safety of treatment with oral once-weekly alendronate 70 mg (n=519), twice-weekly alendronate 35 mg (n=369), and daily alendronate 10 mg (n=370) in a one-year, double-blind, multicenter study of postmenopausal women (ages 42 to 95) with osteoporosis (bone mineral density [bmd] of either lumbar spine or femoral neck at "Alendronate-induced unmasking or deterioration of coeliac disease: a case series", "Late-Onset Psychosis and Risedronate Treatment for Osteoporosis: A Case Report", "Risedronate-related Localized Amnesia in an Elderly Patient with Osteoporosis", "A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study", Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Arthritis (form of joint disorder that involves inflammation of one or more joints), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Foot deformity (functional disability of foot), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), General physical health deterioration (weak health status), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hypoaesthesia (reduced sense of touch or sensation), Hypotension (abnormally low blood pressure), Idiopathic pulmonary fibrosis (chronic lung disease), Malaise (a feeling of general discomfort or uneasiness), Mobility decreased (ability to move is reduced), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Osteoarthritis (a joint disease caused by cartilage loss in a joint), Osteonecrosis of jaw (death of bone of jaw), Osteopenia (a condition where bone mineral density is lower than normal), Osteoporosis (bones weak and more likely to break), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Red blood cell sedimentation rate increased, Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints), Synovitis (inflammation of the synovial membrane), The flu (the flu is caused by an influenza virus), Thrombocytopenia (decrease of platelets in blood), Wheezing (a high-pitched whistling sound made while you breath), Aseptic necrosis (the death of bone tissue due to a lack of blood supply), Atelectasis (partial or complete collapse of the lung), Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder), Dehydration (dryness resulting from the removal of water), Drug eruption (adverse drug reaction of the skin), Fainting (loss of consciousness and postural tone), Fibromyalgia (a long-term condition which causes pain all over the body), Gastrointestinal haemorrhage (bleeding gastrointestinal tract), Glossodynia (a burning or painful sensation in the tongue), Helicobacter infection (helicobacter pylori (h. pylori) infects stomach), Hypercalcaemia (elevated calcium (ca+) level in the blood), Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration), Maternal exposure during pregnancy (use of substance during pregnancy), Melaena (the passage of black, tarry stools), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters), Photophobia (extreme sensitivity to light), Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop), Renal failure acute (rapid kidney dysfunction), Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease), Rheumatoid nodule (a local swelling or tissue lump with rheumatoid disease), Sepsis (a severe blood infection that can lead to organ failure and death), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), Synovial cyst (cyst of joint filled with synovial fluid), Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue), Tenderness (pain or discomfort when an affected area is touched), Tendonitis (a condition that causes pain and swelling of tendons), Therapeutic response decreased (less preventive response), Tremor (trembling or shaking movements in one or more parts of your body), Nasarel and Prevacid 24 Hr drug interaction. Alendronate is not recommended for patients with renal impairment where creatinine clearance is less than 35 ml/min, due to lack of experience. Therefore, patients must wait at least 30 minutes after taking alendronate before taking any other oral medicinal product (see sections 4.2 and 5.2). Alendronate is a bisphosphonate. Therefore, somewhat greater accumulation of alendronate in bone might be expected in patients with impaired renal function (see section 4.2). Patient Compliance and Alendronate. In a one-year study in post-menopausal women with osteoporosis the overall safety profiles of Alendronate sodium Once Weekly 70 mg (n=519) and alendronate 10 mg/day (n=370) were similar. Prescription only. During bisphosphonate treatment, all patients should be encouraged to maintain good oral hygiene, receive routine dental check-ups, and report any oral symptoms such as dental mobility, pain, or swelling. Dosage instructions, including remaining upright for at least 30 minutes and taking with a. more Prescription only Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. Alendronate is taken on differing schedules, either once a day or once a week, according to what type of osteoporosis you have. Osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection (including osteomyelitis) has been reported in patients with cancer who are receiving treatment regimens including primarily intravenously administered bisphosphonates. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. This is a condition that causes your bones to get weaker and be more likely to break. Hypocalcaemia. Risedronate sodium has active ingredients of risedronate sodium. Alendronic acid is a type of medicine called a bisphosphonate. But there are other treatments and ways to relieve pain if this is a problem for you. Each tablet contains 70 mg of alendronic acid (equivalent to 91.363 mg of sodium alendronate trihydrate). If you often forget or struggle to take your medication, speak to your doctor about other treatment options. The effects of alendronic acid may occur after 1 month of taking it. Inability to stand or sit upright for at least 30 minutes. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme. Studies in rats have shown that treatment with alendronate during pregnancy was associated with dystocia in dams during parturition which was related to hypocalcaemia. Like everyone else, I weighed everything up and decided what is best for me. | Explore the latest full-text research PDFs, articles, conference . eHealthMe is studying from 7,437 Risedronate sodium users for its effectiveness, alternative drugs and more. Breast-feeding It is unknown whether alendronate/metabolites are excreted into human milk. The relevance to humans is unknown. Milk or antacids should be given to bind alendronate. Total body BMD also increased significantly. And if their beneficial effects cease or drop dramatically due to the safety precaution of "drug holiday," one hasn't even reaped the benefit of the kind of "tradeoff" that doctors are so fond of citing as a rationale for taking unsafe drugs. Generic or not, one name or another, the bisphosphonates all share the same deeply troubling potential-side-effect profile. generic drugs or brand names) are also considered. Protein binding in human plasma is approximately 78%. Opened database successfully add two inverted commas for every one No specific information is available on the treatment of overdose with alendronate. Once-weekly dosing reduces the risk of oesophageal damage. Alendronic acid, ibandronic acid, risedronate sodium and zoledronic acid are bisphosphonates, licensed for treating osteoporosis. There's also more information in our fact sheet. Osteoporosis is defined as BMD of the spine or hip 2.5 SD below the mean value of a normal young population or as a previous fragility fracture, irrespective of BMD. Most patients had relief of symptoms after stopping treatment. - Inability to stand or sit upright for at least 30 minutes. Alendronic acid (as Alendronate sodium) 70 mg. Jan, I hope this helps, and all the best! Dosage instructions, including remaining upright for at least 30 minutes and taking with a. more. Treatment of post-menopausal osteoporosis. In clinical studies there was no age-related difference in the efficacy or safety profiles of alendronate. 9 users are following. And if the meds' mechanism for improving bone density is to make the bones harder in a way that renders them more brittle, the meds themselves end up increasing the risk of the "atypical femoral fractures" that have been reported, which defeats their very purpose. We all have different factors in our lives and naturally, they contribute to our decisions. But there are other, have a condition called Barretts oesophagus, a tablet that you dissolve in water and drink, inflamed food pipe, sore throat, difficulty swallowing, or heartburn, diarrhoea (frequent or runny bowel movements), constipation (difficulty emptying your bowels). Due to the positive effects of alendronate in increasing bone mineral, decreases in serum calcium and phosphate may occur especially in patients taking glucocorticoids in whom calcium absorption may be decreased.